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jag1a


Official Full Name
jagged canonical Notch ligand 1a
Organism
Danio rerio
Gene ID
140421
Background
Predicted to enable Notch binding activity. Involved in positive regulation of hematopoietic stem cell differentiation. Acts upstream of or within several processes, including hematopoietic stem cell differentiation; regulation of non-canonical NF-kappaB signal transduction; and thyroid gland development. Is active in plasma membrane. Is expressed in several structures, including digestive system; lens placode; nervous system; neural keel; and neural tube. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
jag1; cb243; sb:cb243; serrateC

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