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IL1B


Official Full Name
interleukin 1 beta
Organism
Homo sapiens
Gene ID
3553
Background
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020]
Synonyms
IL-1; IL1F2; IL1beta; IL1-BETA

Cat.No. Product Name Price
SHH318489 shRNA set against Human IL1B (NM_000576.2) Inquiry
SHH318493 shRNA set against Mouse IL1B (NM_008361.3) Inquiry
SHH318497 shRNA set against Rat IL1B (NM_031512.2) Inquiry
SHL171910 shRNA set against Human IL1B(NM_000576.2) Inquiry
SHL171926 shRNA set against Rat Il1b(NM_031512.2) Inquiry
SHL172074 shRNA set against Mouse Il1b(NM_008361.3) Inquiry
SHW005036 shRNA set against Chicken IL1B (NM_204524) Inquiry
SHW017992 shRNA set against Danio rerio IL1B (NM_212844) Inquiry
Cat.No. Product Name Price
CDCB166511 Chicken IL1B ORF Clone (NM_204524) Inquiry
CDFH009164 Human IL1B cDNA Clone(NM_000576.2) Inquiry
CDFR012674 Rat Il1b cDNA Clone(NM_031512.2) Inquiry
MiUTR1H-04888 IL1B miRNA 3'UTR clone Inquiry
MiUTR1M-05989 IL1B miRNA 3'UTR clone Inquiry
MiUTR1R-02632 IL1B miRNA 3'UTR clone Inquiry
CDCB156872 Canine IL1B ORF clone (NM_001037971.1) Inquiry
CDCB156935 Cynomolgus IL1B ORF clone Inquiry
CDCB179467 Danio rerio IL1B ORF Clone (NM_212844) Inquiry
CDCB180206 Rabbit IL1B ORF clone (NM_001082201.1) Inquiry
CDCL184807 Human IL1F2 ORF clone(NM_000576.2) Inquiry
CDCL184808 Mouse IL1F2 ORF clone(NM_008361.3) Inquiry
CDCL184809 Rat IL1F2 ORF clone(NM_031512.2) Inquiry
CDCS405761 Human IL1B ORF Clone (BC008678) Inquiry
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