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fam213aa


Official Full Name
selenoprotein U 1a
Organism
Danio rerio
Gene ID
323739
Background
The protein encoded by this gene belongs to a subfamily of FAM213A/selenoprotein U (SelU), within a peroxiredoxin-like FAM213 superfamily. SelU is unusual in that it has restricted phylogenetic distribution in vertebrates, such as in chicken and fish. Other vertebrate members of this family, including mammals, contain cysteine-containing homologues. SelU proteins contain UxxC (U for selenocysteine and C for cysteine) motif in place of the catalytic CxxC motif found in cysteine-containing homologues. The latter function as redox regulatory proteins, suggesting a similar role for SelU proteins. Like majority of selenoproteins, SelU contains a single selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. A paralog of this gene exists on chromosome 12 (GeneID:767744). [provided by RefSeq, Aug 2017]
Synonyms
selu; sepu; selu1; prxl2a; fam213a; fc08d10; selenou; fam213aa; zgc:73311; wu:fb06a02; wu:fc08d10

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