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dnmt4


Official Full Name
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1
Organism
Danio rerio
Gene ID
317744
Background
Predicted to enable DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates and DNA binding activity. Acts upstream of or within several processes, including Kupffer's vesicle development; hematopoietic stem cell homeostasis; and negative regulation of gene expression via chromosomal CpG island methylation. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); facioscapulohumeral muscular dystrophy 4; immunodeficiency-centromeric instability-facial anomalies syndrome 1; and thymoma. Orthologous to human DNMT3B (DNA methyltransferase 3 beta). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
cb633; dnmt4; dnmt3b

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