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CYP3A4


Official Full Name
cytochrome P450 family 3 subfamily A member 4
Organism
Homo sapiens
Gene ID
1576
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2020]
Synonyms
HLP; CP33; CP34; CYP3A; NF-25; VDDR3; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1

Cat.No. Product Name Price
SHH273485 shRNA set against Human CYP3A4 (NM_017460.5) Inquiry
SHH273489 shRNA set against Mouse CYP3A4 (NM_177380.3) Inquiry
SHG217511 shRNA set against Rat Cyp3a11(NM_153312.2) Inquiry
SHH273445 shRNA set against Human CYP3A (NM_000765.3) Inquiry
SHH273449 shRNA set against Mouse CYP3A (NM_001105160.1) Inquiry
SHH273453 shRNA set against Rat CYP3A (NM_145782.1) Inquiry
SHH273457 shRNA set against Mouse Cyp3a11 (NM_007818.3) Inquiry
SHH273521 shRNA set against Rat Cyp3a62 (NM_001024232.1) Inquiry
SHW017835 shRNA set against Danio rerio CYP3C1 (NM_212673) Inquiry
Cat.No. Product Name Price
CDCR052748 Human CYP3A4 ORF clone (NM_001202855.2) Inquiry
CDFR003509 Rat Cyp3a62 cDNA Clone(NM_001024232.1) Inquiry
MiUTR1M-03547 CYP3A11 miRNA 3'UTR clone Inquiry
MiUTR1R-01347 CYP3A23/3A1 miRNA 3'UTR clone Inquiry
MiUTR1R-01348 CYP3A62 miRNA 3'UTR clone Inquiry
MiUTR3H-00615 CYP3A4 miRNA 3'UTR clone Inquiry
CDCB160288 Human CYP3A4 ORF clone (NM_017460.3) Inquiry
CDCB179310 Danio rerio CYP3C1 ORF Clone (NM_212673) Inquiry
CDCR052744 Mouse Cyp3a11 ORF clone (NM_007818.3) Inquiry
CDCR370560 Rat Cyp3a62 ORF Clone(NM_001024232.1) Inquiry
CDCS409587 Human CYP3A4 ORF Clone (BC069418) Inquiry
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