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col1a1a


Official Full Name
collagen, type I, alpha 1a
Organism
Danio rerio
Gene ID
337158
Background
Predicted to be an extracellular matrix structural constituent conferring tensile strength. Acts upstream of or within several processes, including bone mineralization involved in bone maturation; collagen fibril organization; and fin development. Located in cytoplasm. Is expressed in several structures, including fin; integument; musculature system; nervous system; and skeletal system. Used to study osteogenesis imperfecta and osteogenesis imperfecta type 3. Human ortholog(s) of this gene implicated in several diseases, including Ehlers-Danlos syndrome arthrochalasia type 1; aggressive periodontitis; bone disease (multiple); cutaneous leishmaniasis; and dentinogenesis imperfecta. Orthologous to human COL1A1 (collagen type I alpha 1 chain). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
cb21; col1a1; sb:cb21; sb:cb384; alpha1(I); wu:fa99c12; wu:fb02c06

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