Pages
Products

CLCF1


Official Full Name
cardiotrophin like cytokine factor 1
Organism
Homo sapiens
Gene ID
23529
Background
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Synonyms
CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1

Cat.No. Product Name Price
SHG179881 shRNA set against Mouse Clcf1(NM_019952.3) Inquiry
SHG179899 shRNA set against Rat Clcf1(NM_207615.2) Inquiry
SHG179917 shRNA set against Human CLCF1(NM_013246.2) Inquiry
SHH264542 shRNA set against Human CLCF1 (NM_013246.2) Inquiry
SHH264545 shRNA set against Rat CLCF1 (NM_207615.2) Inquiry
Cat.No. Product Name Price
CDFH003762 Human CLCF1 cDNA Clone(NM_001166212.1) Inquiry
CDFH003763 Human CLCF1 cDNA Clone(NM_013246.2) Inquiry
CDFR015364 Rat Clcf1 cDNA Clone(NM_207615.2) Inquiry
MiUTR1H-02183 CLCF1 miRNA 3'UTR clone Inquiry
MiUTR1M-03072 CLCF1 miRNA 3'UTR clone Inquiry
MiUTR1R-01018 CLCF1 miRNA 3'UTR clone Inquiry
CDCB184164 Rabbit CLCF1 ORF clone (XM_002709238.2) Inquiry
CDCL183576 Human CLCF1 ORF clone(NM_013246.2) Inquiry
CDCL183577 Mouse CLCF1 ORF clone(NM_019952.3) Inquiry
CDCR047534 Human CLCF1 ORF clone (NM_001166212.1) Inquiry
CDCR382440 Rat Clcf1 ORF Clone(NM_207615.2) Inquiry
Quick Inquiry