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CHMP4B


Official Full Name
charged multivesicular body protein 4B
Organism
Homo sapiens
Gene ID
128866
Background
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]
Synonyms
SNF7; CTPP3; Shax1; CHMP4A; SNF7-2; VPS32B; CTRCT31; Vps32-2; C20orf178; dJ553F4.4

Cat.No. Product Name Price
SHG175753 shRNA set against Mouse Chmp4b(NM_029362.3) Inquiry
SHH263217 shRNA set against Human CHMP4B (NM_176812.4) Inquiry
SHH263221 shRNA set against Mouse CHMP4B (NM_029362.3) Inquiry
SHW000373 shRNA set against Chicken CHMP4B (NM_001006286) Inquiry
SHW018512 shRNA set against Danio rerio CHMP4B (NM_213457) Inquiry
Cat.No. Product Name Price
MiUTR1M-03006 CHMP4B miRNA 3'UTR clone Inquiry
MiUTR3H-11538 CHMP4B miRNA 3'UTR clone Inquiry
CDCB159462 Human CHMP4B ORF clone (BC033859) Inquiry
CDCB161848 Chicken CHMP4B ORF Clone (NM_001006286) Inquiry
CDCB179987 Danio rerio CHMP4B ORF Clone (NM_213457) Inquiry
CDCB189083 Rabbit CHMP4B ORF clone (XM_002710799.2) Inquiry
CDCR262547 Mouse Chmp4b ORF Clone(NM_029362.3) Inquiry
CDCS417536 Human CHMP4B ORF Clone (BC033859) Inquiry
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