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caspase-8

Official Full Name
caspase 8, apoptosis-related cysteine peptidase
Organism
Danio rerio
GeneID
58022
Background
Predicted to enable cysteine-type endopeptidase activity. Acts upstream of or within positive regulation of apoptotic process and symbiont-mediated activation of host apoptosis. Predicted to be part of CD95 death-inducing signaling complex. Predicted to be active in cytoplasm. Is expressed in several structures, including axis; germ ring; intestine; male organism; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and lung cancer. Orthologous to human CASP8 (caspase 8). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
caspase-8; zgc:92075;

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