Pages
Products

C11ORF73


Official Full Name
heat shock protein nuclear import factor hikeshi
Organism
Homo sapiens
Gene ID
51501
Background
This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress. [provided by RefSeq, Apr 2016]
Synonyms
HIKESHI; HLD13; L7RN6; OPI10; HSPC138; HSPC179; C11orf73

Cat.No. Product Name Price
SHH248954 shRNA set against Human C11orf73 (NM_016401.3) Inquiry
Cat.No. Product Name Price
MiUTR3H-13861 C11ORF73 miRNA 3'UTR clone Inquiry
CDCB159134 Human C11ORF73 ORF clone (BC001677) Inquiry
CDCS414277 Human C11orf73 ORF Clone (BC001677) Inquiry
CDCS414278 Human C11orf73 ORF Clone (BC018080) Inquiry
Quick Inquiry