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BC067047


Official Full Name
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Organism
Mus musculus
Gene ID
277360
Background
Predicted to enable GTPase activator activity; guanyl-nucleotide exchange factor activity; and phospholipid binding activity. Acts upstream of or within several processes, including neutrophil chemotaxis; positive regulation of GTPase activity; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to be located in several cellular components, including dendritic shaft; growth cone; and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including liver; nervous system; palatal shelf; skeleton; and testis. Used to study autism spectrum disorder. Orthologous to human PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
Prex1; Setd6; P-REX1; G630042G04

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