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arhgef1a


Official Full Name
Rho guanine nucleotide exchange factor (GEF) 2a
Organism
Danio rerio
Gene ID
368266
Background
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including actin filament organization; positive regulation of neuron differentiation; and regulation of Rho protein signal transduction. Predicted to act upstream of or within several processes, including cell division; innate immune response; and nervous system development. Predicted to be located in several cellular components, including Golgi apparatus; bicellular tight junction; and spindle. Predicted to be active in cytoskeleton and ruffle membrane. Is expressed in several structures, including blood vessel; hindbrain neural plate; immature eye; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in immunodeficiency 62 and neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to several human genes including ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
cb473; arhgef1; arhgef1a; zgc:158261; si:dkey-240h12.3

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