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A430078G23RIK


Official Full Name
Rho/Rac guanine nucleotide exchange factor 18
Organism
Mus musculus
Gene ID
102098
Background
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of stress fiber assembly; protein localization to cell-cell junction; and regulation of Rho protein signal transduction. Predicted to act upstream of or within actin cytoskeleton organization; regulation of cell shape; and small GTPase-mediated signal transduction. Predicted to be located in apical part of cell and cytosol. Predicted to be active in plasma membrane. Is expressed in brain; genitourinary system; integument; and liver. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
ASIC1; accn2c; ASIC1-C; zASIC1.3

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