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ZP3


Official Full Name
zona pellucida glycoprotein 3
Organism
Homo sapiens
Gene ID
7784
Background
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]
Synonyms
ZPC; ZP3A; ZP3B; Zp-3; OOMD3; OZEMA3

Cat.No. Product Name Price
SHL162720 shRNA set against Mouse Zp3(NM_011776.1) Inquiry
SHW014804 shRNA set against Danio rerio ZP3 (NM_131331) Inquiry
SHH455744 shRNA set against Human Zp3 (NM_007155.5) Inquiry
SHH455748 shRNA set against Mouse Zp3 (NM_011776.1) Inquiry
SHH455752 shRNA set against Rat Zp3 (NM_053762.1) Inquiry
SHL162620 shRNA set against Human ZP3(NM_007155.5) Inquiry
SHL162638 shRNA set against Rat Zp3(NM_053762.1) Inquiry
SHW004902 shRNA set against Chicken ZP3 (NM_204389) Inquiry
SHW015107 shRNA set against Danio rerio ZP3B (NM_131696) Inquiry
Cat.No. Product Name Price
CDFH022195 Human ZP3 cDNA Clone(NM_001110354.1) Inquiry
CDFR013444 Rat Zp3 cDNA Clone(NM_053762.1) Inquiry
MiUTR1H-11751 ZP3 miRNA 3'UTR clone Inquiry
MiUTR1M-13208 ZP3 miRNA 3'UTR clone Inquiry
MiUTR1R-08738 ZP3 miRNA 3'UTR clone Inquiry
CDCB166377 Chicken ZP3 ORF Clone (NM_204389) Inquiry
CDCB176279 Danio rerio ZP3 ORF Clone (NM_131331) Inquiry
CDCB176582 Danio rerio ZP3B ORF Clone (NM_131696) Inquiry
CDCB181223 Rabbit ZP3 ORF clone (NM_001195720.1) Inquiry
CDCH106440 human ZP3 ORF clone (NM_001110354.1) Inquiry
CDCH106442 human ZP3 ORF clone (NM_007155.5) Inquiry
CDCH106444 Mouse Zp3 ORF clone (NM_011776.1) Inquiry
CDCR380542 Rat Zp3 ORF Clone(NM_053762.1) Inquiry
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