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XBP1


Official Full Name
X-box binding protein 1
Organism
Homo sapiens
Gene ID
7494
Background
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
Synonyms
XBP2; TREB5; XBP-1; TREB-5

Cat.No. Product Name Price
SHH447692 shRNA set against Human Xbp1 (NM_005080.3) Inquiry
SHH447696 shRNA set against Mouse Xbp1 (NM_013842.2) Inquiry
SHH447700 shRNA set against Rat Xbp1 (NM_001004210.1) Inquiry
SHL137530 shRNA set against Rat Xbp1(NM_001004210.1) Inquiry
SHL137548 shRNA set against Human XBP1(NM_001079539.1) Inquiry
SHL137601 shRNA set against Mouse Xbp1(NM_013842.2) Inquiry
SHW000283 shRNA set against Chicken XBP1 (NM_001006192) Inquiry
SHW015264 shRNA set against Danio rerio XBP1 (NM_131874) Inquiry
Cat.No. Product Name Price
CDFH021345 Human XBP1 cDNA Clone(NM_001079539.1) Inquiry
CDFR001358 Rat Xbp1 cDNA Clone(NM_001004210.1) Inquiry
MiUTR1H-11301 XBP1 miRNA 3'UTR clone Inquiry
MiUTR1M-12828 XBP1 miRNA 3'UTR clone Inquiry
MiUTR1R-08603 XBP1 miRNA 3'UTR clone Inquiry
MiUTR3H-02417 XBP1 miRNA 3'UTR clone Inquiry
CDCB161758 Chicken XBP1 ORF Clone (NM_001006192) Inquiry
CDCB176739 Danio rerio XBP1 ORF Clone (NM_131874) Inquiry
CDCB193673 Rabbit XBP1 ORF clone (XM_008274627.1) Inquiry
CDCH101658 human XBP1 ORF clone (NM_001079539.1) Inquiry
CDCL186784 Human XBP1 ORF clone(NM_005080.3) Inquiry
CDCL186785 Mouse XBP1 ORF clone(NM_013842.2) Inquiry
CDCR368409 Rat Xbp1 ORF Clone(NM_001004210.1) Inquiry
CDCS407264 Human XBP1 ORF Clone (BC000938) Inquiry
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