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WNK4

Official Full Name
WNK lysine deficient protein kinase 4
Organism
Homo sapiens
GeneID
65266
Background
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]
Synonyms
PHA2B; PRKWNK4;

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