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WISP1


Official Full Name
cellular communication network factor 4
Organism
Homo sapiens
Gene ID
8840
Background
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]
Synonyms
CCN4; WISP1; WISP1c; WISP1i; WISP1tc; WISP1-OT1; WISP1-UT1

Cat.No. Product Name Price
SHH436056 shRNA set against Human TSGA13 (NM_052933.2) Inquiry
SHH436060 shRNA set against Mouse TSGA13 (NM_054073.2) Inquiry
SHH436064 shRNA set against Rat TSGA13 (NM_001107851.1) Inquiry
SHH447096 shRNA set against Human WISP1 (NM_003882.3) Inquiry
SHH447100 shRNA set against Mouse WISP1 (NM_018865.2) Inquiry
SHH447104 shRNA set against Rat WISP1 (NM_031716.1) Inquiry
SHL021162 shRNA set against Mouse Tsga13(NM_054073.2) Inquiry
SHL099028 shRNA set against Human TSGA13(NM_052933.2) Inquiry
SHL135498 shRNA set against Rat Wisp1(NM_031716.1) Inquiry
SHL135570 shRNA set against Human WISP1(NM_080838.2) Inquiry
SHL135588 shRNA set against Mouse Wisp1(NM_018865.2) Inquiry
SHW001126 shRNA set against Chicken WISP1 (NM_001024579) Inquiry
Cat.No. Product Name Price
MiUTR3H-05930 WISP1 miRNA 3'UTR clone Inquiry
MiUTR1M-12804 WISP1 miRNA 3'UTR clone Inquiry
MiUTR1M-12217 TSGA13 miRNA 3'UTR clone Inquiry
MiUTR1H-11271 WISP1 miRNA 3'UTR clone Inquiry
MiUTR1H-10807 TSGA13 miRNA 3'UTR clone Inquiry
CDFR012852 Rat Wisp1 cDNA Clone(NM_031716.1) Inquiry
CDFR007502 Rat Tsga13 cDNA Clone(NM_001107851.1) Inquiry
CDFG007044 Human TSGA13 cDNA Clone(NM_052933.2) Inquiry
MiUTR1R-08592 WISP1 miRNA 3'UTR clone Inquiry
CDCS419866 Human TSGA13 ORF Clone (BC038415) Inquiry
CDCR379866 Rat Wisp1 ORF Clone(NM_031716.1) Inquiry
CDCR314372 Human TSGA13 ORF Clone(NM_052933.2) Inquiry
CDCR264579 Mouse Tsga13 ORF Clone(NM_054073.2) Inquiry
CDCR253682 Mouse Wisp1 ORF Clone(NM_018865.2) Inquiry
CDCH101368 human WISP1 ORF clone (NM_001204869.1) Inquiry
CDCH101366 human WISP1 ORF clone (NM_001204870.1) Inquiry
CDCB195525 Rabbit WISP1 ORF clone (XM_002710622.2) Inquiry
CDCB190636 Rabbit TSGA13 ORF clone (XM_008258126.1) Inquiry
CDCR374525 Rat Tsga13 ORF Clone(NM_001107851.1) Inquiry
CDCB162601 Chicken WISP1 ORF Clone (NM_001024579) Inquiry
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