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WRNIP1


Official Full Name
WRN helicase interacting protein 1
Organism
Homo sapiens
Gene ID
56897
Background
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
Synonyms
WHIP; FAP93; CFAP93; bA420G6.2

Cat.No. Product Name Price
SHH447464 shRNA set against Human WRNIP1 (NM_020135.2) Inquiry
SHH447468 shRNA set against Mouse WRNIP1 (NM_030215.3) Inquiry
SHH447472 shRNA set against Rat WRNIP1 (NM_172332.2) Inquiry
SHL136606 shRNA set against Human WRNIP1(NM_020135.2) Inquiry
SHL136674 shRNA set against Rat Wrnip1(NM_172332.2) Inquiry
SHW018059 shRNA set against Danio rerio WRNIP1 (NM_212920) Inquiry
Cat.No. Product Name Price
CDFG002482 Human WRNIP1 cDNA Clone(NM_020135.2) Inquiry
CDFR014754 Rat Wrnip1 cDNA Clone(NM_172332.2) Inquiry
MiUTR1H-11288 WRNIP1 miRNA 3'UTR clone Inquiry
MiUTR1R-08597 WRNIP1 miRNA 3'UTR clone Inquiry
MiUTR3H-09836 WRNIP1 miRNA 3'UTR clone Inquiry
CDCB179534 Danio rerio WRNIP1 ORF Clone (NM_212920) Inquiry
CDCB185682 Rabbit WRNIP1 ORF clone (XM_008274286.1) Inquiry
CDCH101528 human WRNIP1 ORF clone (NM_020135.2) Inquiry
CDCH404099 Human WRNIP1 ORF clone(NM_130395.2) Inquiry
CDCR263491 Mouse Wrnip1 ORF Clone(NM_030215.3) Inquiry
CDCR381805 Rat Wrnip1 ORF Clone(NM_172332.2) Inquiry
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