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WDFY3

Official Full Name
WD repeat and FYVE domain containing 3
Organism
Homo sapiens
GeneID
23001
Background
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]
Synonyms
ALFY; BCHS; MCPH18; ZFYVE25;

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