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VTN


Official Full Name
vitronectin
Organism
Homo sapiens
Gene ID
7448
Background
The protein encoded by this gene functions in part as an adhesive glycoprotein. Differential expression of this protein can promote either cell adhesion or migration as it links cells to the extracellular matrix through a variety of ligands. These ligands include integrins, plasminogen activator inhibitor-1, and urokinase plasminogen activator receptor. This secreted protein can be present in the plasma as a monomer or dimer and forms a multimer in the extracellular matrix of several tissues. This protein also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors. This protein can also promote extracellular matrix degradation and thus plays a role in tumorigenesis. It is involved in a variety of other biological processes such as the regulation of the coagulation pathway, wound healing, and tissue remodeling. The heparin-binding domain of this protein give it anti-microbial properties. It is also a lipid binding protein that forms a principal component of high density lipoprotein. [provided by RefSeq, Aug 2020]
Synonyms
VN; V75; VNT

Cat.No. Product Name Price
SHH445376 shRNA set against Human VTN (NM_000638.3) Inquiry
SHH445380 shRNA set against Mouse VTN (NM_011707.2) Inquiry
SHH445384 shRNA set against Rat VTN (NM_019156.2) Inquiry
SHL128950 shRNA set against Rat Vtn(NM_019156.2) Inquiry
SHL129072 shRNA set against Human VTN(NM_000638.3) Inquiry
SHW005561 shRNA set against Chicken VTN (NM_205061) Inquiry
Cat.No. Product Name Price
CDFH021169 Human VTN cDNA Clone(NM_000638.3) Inquiry
CDFR011454 Rat Vtn cDNA Clone(NM_019156.2) Inquiry
MiUTR1H-11177 VTN miRNA 3'UTR clone Inquiry
MiUTR1R-08553 VTN miRNA 3'UTR clone Inquiry
CDCB167036 Chicken VTN ORF Clone (NM_205061) Inquiry
CDCB180533 Rabbit VTN ORF clone (NM_001082292.1) Inquiry
CDCR378497 Rat Vtn ORF Clone(NM_019156.2) Inquiry
CDCS405811 Human VTN ORF Clone (BC005046) Inquiry
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