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UBE3A


Official Full Name
ubiquitin protein ligase E3A
Organism
Homo sapiens
Gene ID
7337
Background
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Synonyms
AS; ANCR; PIX1; E6-AP; HPVE6A; EPVE6AP

Cat.No. Product Name Price
SHG057475 shRNA set against Human UBE3A(NM_130838.1) Inquiry
SHH439252 shRNA set against Human UBE3A (NM_000462.3) Inquiry
SHH439256 shRNA set against Mouse UBE3A (NM_173010.3) Inquiry
SHL111838 shRNA set against Mouse Ube3a(NM_011668.2) Inquiry
SHL111842 shRNA set against Mouse Ube3a(NM_173010.3) Inquiry
SHL111942 shRNA set against Mouse Ube3a(NM_001033962.1) Inquiry
SHL111960 shRNA set against Mouse Ube3a(NM_011668.2) Inquiry
SHW007596 shRNA set against Danio rerio UBE3A (NM_001007318) Inquiry
Cat.No. Product Name Price
CDFG007630 Human UBE3A cDNA Clone(NM_130838.1) Inquiry
CDFG018050 Mouse Ube3a cDNA Clone(NM_001033962.1) Inquiry
CDFL014595 Mouse Ube3a cDNA Clone(NM_011668.2) Inquiry
MiUTR1M-12399 UBE3A miRNA 3'UTR clone Inquiry
MiUTR1M-12400 UBE3A miRNA 3'UTR clone Inquiry
MiUTR3H-04261 UBE3A miRNA 3'UTR clone Inquiry
MiUTR3H-04262 UBE3A miRNA 3'UTR clone Inquiry
MiUTR3H-04263 UBE3A miRNA 3'UTR clone Inquiry
CDCB169071 Danio rerio UBE3A ORF Clone (NM_001007318) Inquiry
CDCB191998 Rabbit UBE3A ORF clone (XM_008269755.1) Inquiry
CDCH097548 Mouse Ube3a ORF clone (NM_001033962.1) Inquiry
CDCH097550 Mouse Ube3a ORF clone (NM_011668.2) Inquiry
CDCR271986 Mouse Ube3a ORF Clone(NM_173010.3) Inquiry
CDCR315856 Human UBE3A ORF Clone(NM_130839.2) Inquiry
CDCS405675 Human UBE3A ORF Clone (BC009271) Inquiry
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