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UQCRB

Official Full Name
ubiquinol-cytochrome c reductase binding protein
Organism
Homo sapiens
GeneID
7381
Background
This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]
Synonyms
QPC; QCR7; QP-C; UQBC; UQBP; UQPC; UQCR6; MC3DN3;

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