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UPF3B


Official Full Name
UPF3B regulator of nonsense mediated mRNA decay
Organism
Homo sapiens
Gene ID
65109
Background
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms
MRX62; MRX82; UPF3X; HUPF3B; MRXS14; RENT3B; UPF3BP1; UPF3BP2; UPF3BP3; Upf3p-X

Cat.No. Product Name Price
SHH440766 shRNA set against Human UPF3B (NM_023010.3) Inquiry
SHH440768 shRNA set against Mouse UPF3B (NM_026573.2) Inquiry
SHH440772 shRNA set against Rat UPF3B (NM_001135873.1) Inquiry
SHL115558 shRNA set against Mouse Upf3b(NM_026573.2) Inquiry
SHW017077 shRNA set against Danio rerio UPF3B (NM_200954) Inquiry
Cat.No. Product Name Price
CDFL014705 Mouse Upf3b cDNA Clone(NM_026573.2) Inquiry
CDFR010225 Rat Upf3b cDNA Clone(NM_001135873.1) Inquiry
MiUTR1M-12476 UPF3B miRNA 3'UTR clone Inquiry
MiUTR3H-02691 UPF3B miRNA 3'UTR clone Inquiry
MiUTR3H-02692 UPF3B miRNA 3'UTR clone Inquiry
CDCB178552 Danio rerio UPF3B ORF Clone (NM_200954) Inquiry
CDCB192719 Rabbit UPF3B ORF clone (XM_002720125.2) Inquiry
CDCH098364 Mouse Upf3b ORF clone (NM_026573.2) Inquiry
CDCR377138 Rat Upf3b ORF Clone(NM_001135873.1) Inquiry
CDCS415591 Human UPF3B ORF Clone (BC121017) Inquiry
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