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UHRF1


Official Full Name
ubiquitin like with PHD and ring finger domains 1
Organism
Homo sapiens
Gene ID
29128
Background
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
Synonyms
Np95; hNP95; ICBP90; RNF106; TDRD22; hUHRF1; huNp95

Cat.No. Product Name Price
SHL113984 shRNA set against Human UHRF1(NM_013282.3) Inquiry
SHH440304 shRNA set against Rat Uhrf1 (NM_001008882.1) Inquiry
SHL114002 shRNA set against Mouse Uhrf1(NM_010931.3) Inquiry
SHL114020 shRNA set against Human UHRF1(NM_001048201.1) Inquiry
SHW018192 shRNA set against Danio rerio UHRF1 (NM_213077) Inquiry
Cat.No. Product Name Price
CDCH098088 human UHRF1 ORF clone (NM_013282.3) Inquiry
CDCS407158 Human UHRF1 ORF Clone (BC113875) Inquiry
CDFH020843 Human UHRF1 cDNA Clone(NM_001048201.1) Inquiry
CDFH020845 Human UHRF1 cDNA Clone(NM_013282.3) Inquiry
CDFR002029 Rat Uhrf1 cDNA Clone(NM_001008882.1) Inquiry
MiUTR1H-10999 UHRF1 miRNA 3'UTR clone Inquiry
MiUTR1H-11000 UHRF1 miRNA 3'UTR clone Inquiry
MiUTR1M-12454 UHRF1 miRNA 3'UTR clone Inquiry
MiUTR1R-08347 UHRF1 miRNA 3'UTR clone Inquiry
CDCB179667 Danio rerio UHRF1 ORF Clone (NM_213077) Inquiry
CDCH098090 Mouse Uhrf1 ORF clone (NM_001111079.1) Inquiry
CDCH098092 Mouse Uhrf1 ORF clone (NM_001111078.1) Inquiry
CDCH098098 human UHRF1 ORF clone (NM_001048201.1) Inquiry
CDCR236698 Mouse Uhrf1 ORF Clone(NM_001111080.1) Inquiry
CDCR249867 Mouse Uhrf1 ORF Clone(NM_010931.3) Inquiry
CDCR369069 Rat Uhrf1 ORF Clone(NM_001008882.1) Inquiry
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