Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome.
UBA52; ubiquitin A-52 residue ribosomal protein fusion product 1; ubiquitin-60S ribosomal protein L40; 60S ribosomal protein L40; CEP52; HUBCEP52; L40; MGC57125; MGC126879; MGC126881; ribosomal protein L40; RPL40; ubiquitin carboxyl extension protein 52; ubiquitin 52 amino acid fusion protein; ubiquitin CEP52; UBA 52; Ubiquitin 60S ribosomal protein L40; Ubiquitin A 52 residue ribosomal protein fusion product 1; ubiquitin-CEP52; ubiquitin-52 amino acid fusion protein; ubiquitin-ribosomal protein fusion protein; wu:fa91f08; zgc:123344