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TYROBP


Official Full Name
transmembrane immune signaling adaptor TYROBP
Organism
Homo sapiens
Gene ID
7305
Background
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
Synonyms
DAP12; KARAP; PLOSL; PLOSL1

Cat.No. Product Name Price
SHH438468 shRNA set against Human TYROBP (NM_003332.3) Inquiry
SHH438472 shRNA set against Mouse TYROBP (NM_011662.2) Inquiry
SHH438476 shRNA set against Rat TYROBP (NM_212525.1) Inquiry
SHL108854 shRNA set against Rat Tyrobp(NM_212525.1) Inquiry
SHL108882 shRNA set against Mouse Tyrobp(NM_011662.2) Inquiry
SHW011759 shRNA set against Danio rerio TYROBP (NM_001100103) Inquiry
Cat.No. Product Name Price
CDFH020685 Human TYROBP cDNA Clone(NM_001173514.1) Inquiry
CDFH020686 Human TYROBP cDNA Clone(NM_001173515.1) Inquiry
CDFR015395 Rat Tyrobp cDNA Clone(NM_212525.1) Inquiry
MiUTR1M-12359 TYROBP miRNA 3'UTR clone Inquiry
MiUTR1R-08300 TYROBP miRNA 3'UTR clone Inquiry
MiUTR3H-06591 TYROBP miRNA 3'UTR clone Inquiry
MiUTR3H-06592 TYROBP miRNA 3'UTR clone Inquiry
CDCB173234 Danio rerio TYROBP ORF Clone (NM_001100103) Inquiry
CDCB182202 Rabbit TYROBP ORF clone (XM_008249547.1) Inquiry
CDCH097094 human TYROBP ORF clone (NM_001173514.1) Inquiry
CDCH097096 human TYROBP ORF clone (NM_001173515.1) Inquiry
CDCH097098 Mouse Tyrobp ORF clone (NM_011662.2) Inquiry
CDCR382172 Rat Tyrobp ORF Clone(NM_212525.1) Inquiry
CDCS417769 Human TYROBP ORF Clone (BC011175) Inquiry
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