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TOP3B


Official Full Name
DNA topoisomerase III beta
Organism
Homo sapiens
Gene ID
8940
Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Synonyms
TOP3B1

Cat.No. Product Name Price
SHH432896 shRNA set against Human TOP3B (NM_003935.3) Inquiry
SHH432900 shRNA set against Mouse TOP3B (NM_011624.2) Inquiry
SHH432904 shRNA set against Rat TOP3B (NM_001105861.1) Inquiry
SHL087518 shRNA set against Mouse Top3b(NM_011624.2) Inquiry
SHL087524 shRNA set against Human TOP3B(NM_003935.3) Inquiry
SHW000272 shRNA set against Chicken TOP3B (NM_001006181) Inquiry
Cat.No. Product Name Price
CDFH020118 Human TOP3B cDNA Clone(NM_003935.3) Inquiry
CDFR005590 Rat Top3b cDNA Clone(NM_001105861.1) Inquiry
MiUTR1H-10645 TOP3B miRNA 3'UTR clone Inquiry
MiUTR1M-12052 TOP3B miRNA 3'UTR clone Inquiry
CDCB161747 Chicken TOP3B ORF Clone (NM_001006181) Inquiry
CDCB190612 Rabbit TOP3B ORF clone (XM_002719725.2) Inquiry
CDCH094020 Mouse Top3b ORF clone (NM_011624.2) Inquiry
CDCR286799 Human TOP3B ORF Clone(NM_003935.3) Inquiry
CDCR372677 Rat Top3b ORF Clone(NM_001105861.1) Inquiry
CDCS411550 Human TOP3B ORF Clone (BC002432) Inquiry
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