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TNNI3


Official Full Name
troponin I3, cardiac type
Organism
Homo sapiens
Gene ID
7137
Background
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020]
Synonyms
CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF

Cat.No. Product Name Price
SHH432392 shRNA set against Human TNNI3 (NM_000363.4) Inquiry
SHH432396 shRNA set against Mouse TNNI3 (NM_009406.3) Inquiry
SHH432400 shRNA set against Rat TNNI3 (NM_017144.2) Inquiry
SHL086286 shRNA set against Human TNNI3(NM_000363.4) Inquiry
SHL086498 shRNA set against Mouse Tnni3(NM_009406.3) Inquiry
SHW006066 shRNA set against Chicken TNNI3 (NM_213570) Inquiry
Cat.No. Product Name Price
MiUTR1H-10620 TNNI3 miRNA 3'UTR clone Inquiry
MiUTR1M-12023 TNNI3 miRNA 3'UTR clone Inquiry
CDCB167541 Chicken TNNI3 ORF Clone (NM_213570) Inquiry
CDCL186592 Human TNNI3 ORF clone(NM_000363.4) Inquiry
CDCR378211 Rat Tnni3 ORF Clone(NM_017144.2) Inquiry
CDCS405606 Human TNNI3 ORF Clone (BC096165) Inquiry
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