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TMEM142A

Official Full Name
ORAI calcium release-activated calcium modulator 1
Organism
Homo sapiens
GeneID
84876
Background
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
Synonyms
ORAI1; IMD9; TAM2; ORAT1; CRACM1; TMEM142A;

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