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TLE3

Official Full Name
TLE family member 3, transcriptional corepressor
Organism
Homo sapiens
GeneID
7090
Background
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Synonyms
ESG; ESG3; GRG3; HsT18976;

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