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TDO2

Official Full Name
tryptophan 2,3-dioxygenase
Organism
Homo sapiens
GeneID
6999
Background
This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]
Synonyms
TO; TDO; TPH2; TRPO; HYPTRP;

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