Pages
Products

TAB1


Official Full Name
TGF-beta activated kinase 1 (MAP3K7) binding protein 1
Organism
Homo sapiens
Gene ID
10454
Background
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Synonyms
3'-Tab1; MAP3K7IP1

Cat.No. Product Name Price
SHH422356 shRNA set against Human TAB1 (NM_006116.2) Inquiry
SHH422360 shRNA set against Mouse TAB1 (NM_025609.2) Inquiry
SHW000329 shRNA set against Chicken TAB1 (NM_001006240) Inquiry
Cat.No. Product Name Price
CDCR292017 Human TAB1 ORF Clone(NM_006116.2) Inquiry
CDFG010126 Human TAB1 cDNA Clone(NM_153497.2) Inquiry
CDFH019137 Human TAB1 cDNA Clone(NM_006116.2) Inquiry
CDFH019138 Human TAB1 cDNA Clone(NM_006116.2) Inquiry
CDFR009228 Rat Tab1 cDNA Clone(NM_001109976.2) Inquiry
MiUTR1H-06066 TAB1 miRNA 3'UTR clone Inquiry
MiUTR1H-06067 TAB1 miRNA 3'UTR clone Inquiry
MiUTR1M-06921 TAB1 miRNA 3'UTR clone Inquiry
CDCB161804 Chicken TAB1 ORF Clone (NM_001006240) Inquiry
CDCB182961 Rabbit TAB1 ORF clone (XM_002711387.2) Inquiry
CDCR320796 Human TAB1 ORF Clone(NM_153497.2) Inquiry
CDCR376275 Rat Tab1 ORF Clone(NM_001109976.2) Inquiry
CDCS419692 Human TAB1 ORF Clone (BC050554) Inquiry
Quick Inquiry