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TUBA1A


Official Full Name
tubulin alpha 1a
Organism
Homo sapiens
Gene ID
7846
Background
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Synonyms
LIS3; TUBA3; B-ALPHA-1

Cat.No. Product Name Price
SHL105920 shRNA set against Mouse Tuba1a(NM_011653.2) Inquiry
SHH437584 shRNA set against Human Tuba1a (NM_006009.3) Inquiry
SHH437588 shRNA set against Mouse Tuba1a (NM_011653.2) Inquiry
SHH437592 shRNA set against Rat Tuba1a (NM_022298.1) Inquiry
Cat.No. Product Name Price
CDCR251090 Mouse Tuba1a ORF Clone(NM_011653.2) Inquiry
CDFR011979 Rat Tuba1a cDNA Clone(NM_022298.1) Inquiry
MiUTR1M-12295 TUBA1A miRNA 3'UTR clone Inquiry
MiUTR1R-08275 TUBA1A miRNA 3'UTR clone Inquiry
MiUTR3H-05063 TUBA1A miRNA 3'UTR clone Inquiry
CDCB156469 Rat TUBA1A ORF clone (BC062238.1) Inquiry
CDCB158665 Human TUBA1A ORF clone (BC006468) Inquiry
CDCB193342 Rabbit TUBA1A ORF clone (XM_002711101.2) Inquiry
CDCR378982 Rat Tuba1a ORF Clone(NM_022298.1) Inquiry
CDCS412526 Human TUBA1A ORF Clone (BC006468) Inquiry
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