Pages
Products

TTN


Official Full Name
titin
Organism
Homo sapiens
Gene ID
7273
Background
This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012]
Synonyms
TMD; CMH9; CMD1G; CMPD4; CMYO5; CMYP5; EOMFC; HMERF; MYLK5; SALMY; LGMD2J; LGMDR10

Cat.No. Product Name Price
SHH437480 shRNA set against Mouse TTN (NM_011652.3) Inquiry
SHH437520 shRNA set against Rat TTR (NM_012681.2) Inquiry
SHH437512 shRNA set against Human TTR (NM_000371.3) Inquiry
SHH437516 shRNA set against Mouse TTR (NM_013697.5) Inquiry
SHL103518 shRNA set against Mouse Ttn(NM_028004.2) Inquiry
SHW004364 shRNA set against Chicken TTR (NM_001281498) Inquiry
SHW005830 shRNA set against Chicken TTR (NM_205335) Inquiry
SHW007324 shRNA set against Danio rerio TTR (NM_001005598) Inquiry
Cat.No. Product Name Price
RP00162 Recombinant Human TTR (C-6His) Inquiry
Cat.No. Product Name Price
MiUTR3H-02230 TTN miRNA 3'UTR clone Inquiry
MiUTR3H-02228 TTN miRNA 3'UTR clone Inquiry
MiUTR3H-02227 TTN miRNA 3'UTR clone Inquiry
CDCB167305 Chicken TTR ORF Clone (NM_205335) Inquiry
MiUTR3H-02226 TTN miRNA 3'UTR clone Inquiry
MiUTR3H-01802 TTR miRNA 3'UTR clone Inquiry
MiUTR1M-12289 TTN miRNA 3'UTR clone Inquiry
MiUTR1M-12288 TTN miRNA 3'UTR clone Inquiry
MiUTR3H-02229 TTN miRNA 3'UTR clone Inquiry
CDCS405617 Human TTR ORF Clone (BC005310) Inquiry
CDCR377543 Rat Ttr ORF Clone(NM_012681.2) Inquiry
CDCR007520 Mouse TTN ORF clone(NM_028004.2) Inquiry
CDCR007515 Human TTN ORF clone(NM_133378.4) Inquiry
CDCL186642 Mouse TTR ORF clone(NM_013697.5) Inquiry
CDCB189421 Rabbit TTR ORF clone (XM_002713486.2) Inquiry
CDCB180204 Rabbit TTN ORF clone (XM_008258794.1) Inquiry
CDCB168799 Danio rerio TTR ORF Clone (NM_001005598) Inquiry
CDCB165839 Chicken TTR ORF Clone (NM_001281498) Inquiry
CDCB160260 Human TTR ORF clone (NM_000371) Inquiry
CDCR007518 Mouse TTN ORF clone(NM_011652.3) Inquiry
CDCB156381 Rat TTR ORF clone (AF479660.1) Inquiry
Quick Inquiry