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tph1b


Official Full Name
tryptophan hydroxylase 1b
Organism
Danio rerio
Gene ID
415103
Background
Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation and response to hypoxia. Predicted to be active in neuron projection. Is expressed in axial mesoderm; axis; epiphysis; margin; and raphe nucleus. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; depressive disorder (multiple); and nicotine dependence. Orthologous to human TPH1 (tryptophan hydroxylase 1). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
tph2; tph1l; tphD2

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