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TNNI1


Official Full Name
troponin I1, slow skeletal type
Organism
Homo sapiens
Gene ID
7135
Background
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]
Synonyms
TNN1; SSTNI

Cat.No. Product Name Price
SHL086394 shRNA set against Rat Tnni1(NM_017184.1) Inquiry
SHH432368 shRNA set against Human TNNI1 (NM_003281.3) Inquiry
SHH432372 shRNA set against Mouse TNNI1 (NM_021467.5) Inquiry
SHH432376 shRNA set against Rat TNNI1 (NM_017184.1) Inquiry
SHL086358 shRNA set against Mouse Tnni1(NM_021467.5) Inquiry
SHL086412 shRNA set against Human TNNI1(NM_003281.3) Inquiry
Cat.No. Product Name Price
CDCR236849 Mouse Tnni1 ORF Clone(NM_001112702.1) Inquiry
CDCR255363 Mouse Tnni1 ORF Clone(NM_021467.5) Inquiry
CDCS411234 Human TNNI1 ORF Clone (BC012600) Inquiry
CDFH020054 Human TNNI1 cDNA Clone(NM_003281.3) Inquiry
CDFH020055 Human TNNI1 cDNA Clone(NM_003281.3) Inquiry
CDFR011236 Rat Tnni1 cDNA Clone(NM_017184.1) Inquiry
MiUTR1H-10619 TNNI1 miRNA 3'UTR clone Inquiry
MiUTR1M-12021 TNNI1 miRNA 3'UTR clone Inquiry
MiUTR1R-08135 TNNI1 miRNA 3'UTR clone Inquiry
CDCB156459 Rat TNNI1 ORF clone (FQ215574.1) Inquiry
CDCB194911 Rabbit TNNI1 ORF clone (XM_008268600.1) Inquiry
CDCR285292 Human TNNI1 ORF Clone(NM_003281.3) Inquiry
CDCR378250 Rat Tnni1 ORF Clone(NM_017184.1) Inquiry
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