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TMEM189-UBE2V1


Official Full Name
PEDS1-UBE2V1 readthrough
Organism
Homo sapiens
Gene ID
387522
Background
The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010]
Synonyms
PEDS1-UBE2V1; CROC1B; CROC-1B; KUA-UEV; TMEM189-UBE2V1

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