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TMEM133

Official Full Name
Rho GTPase activating protein 42
Organism
Homo sapiens
GeneID
143872
Background
This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017]
Synonyms
ARHGAP42; AD031; GRAF3; TMEM133;

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