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TBP


Official Full Name
TATA-box binding protein
Organism
Homo sapiens
Gene ID
6908
Background
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]
Synonyms
HDL4; TBP1; GTF2D; SCA17; TFIID; GTF2D1

Cat.No. Product Name Price
SHH424264 shRNA set against Human TBP (NM_003194.4) Inquiry
SHH424268 shRNA set against Mouse TBP (NM_013684.3) Inquiry
SHH424272 shRNA set against Rat TBP (NM_001004198.1) Inquiry
SHW005603 shRNA set against Chicken TBP (NM_205103) Inquiry
SHW016334 shRNA set against Danio rerio TBP (NM_200096) Inquiry
Cat.No. Product Name Price
CDCR356405 Human TBP ORF Clone(NM_001172085.1) Inquiry
CDCR368397 Rat Tbp ORF Clone(NM_001004198.1) Inquiry
CDFH019284 Human TBP cDNA Clone(NM_001172085.1) Inquiry
CDFR001346 Rat Tbp cDNA Clone(NM_001004198.1) Inquiry
MiUTR1H-10236 TBP miRNA 3'UTR clone Inquiry
MiUTR1R-07923 TBP miRNA 3'UTR clone Inquiry
MiUTR3H-03128 TBP miRNA 3'UTR clone Inquiry
SKO0239 TBP Validated sgRNA vector Inquiry
CDCB167078 Chicken TBP ORF Clone (NM_205103) Inquiry
CDCB177809 Danio rerio TBP ORF Clone (NM_200096) Inquiry
CDCB191703 Rabbit TBP ORF clone (XM_002723497.2) Inquiry
CDCL186377 Human TBP ORF clone(NM_003194.4) Inquiry
CDCS408996 Human TBP ORF Clone (BC109054) Inquiry
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