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SPRED1

Official Full Name
sprouty related EVH1 domain containing 1
Organism
Homo sapiens
GeneID
161742
Background
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]
Synonyms
LGSS; NFLS; hSpred1; spred-1; PPP1R147;

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