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SPINT2

Official Full Name
serine peptidase inhibitor, Kunitz type 2
Organism
Homo sapiens
GeneID
10653
Background
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Synonyms
PB; Kop; HAI2; DIAR3; HAI-2;

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