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SPG21

Official Full Name
SPG21 abhydrolase domain containing, maspardin
Organism
Homo sapiens
GeneID
51324
Background
The protein encoded by this gene binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. Mutations in this gene are associated with autosomal recessive spastic paraplegia 21 (SPG21), also known as mast syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Synonyms
MAST; ACP33; GL010; ABHD21; BM-019;

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