Pages
Products

SPAG1


Official Full Name
sperm associated antigen 1
Organism
Homo sapiens
Gene ID
6674
Background
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]
Synonyms
SP75; TPIS; CT140; CILD28; DNAAF13; HSD-3.8; HEL-S-268

Cat.No. Product Name Price
LV26382L human SPAG1 (NM_172218) lentivirus particles Inquiry
Cat.No. Product Name Price
SHH415768 shRNA set against Human Spag1 (NM_003114.4) Inquiry
SHH415772 shRNA set against Mouse Spag1 (NM_012031.3) Inquiry
SHH415776 shRNA set against Rat Spag1 (NM_001012116.1) Inquiry
SHL025452 shRNA set against Rat Spag1(NM_001012116.1) Inquiry
SHL025470 shRNA set against Mouse Spag1(NM_012031.3) Inquiry
Cat.No. Product Name Price
CDCR251761 Mouse Spag1 ORF Clone(NM_012031.3) Inquiry
CDFR002543 Rat Spag1 cDNA Clone(NM_001012116.1) Inquiry
MiUTR1M-11117 SPAG1 miRNA 3'UTR clone Inquiry
MiUTR1R-07628 SPAG1 miRNA 3'UTR clone Inquiry
MiUTR3H-05927 SPAG1 miRNA 3'UTR clone Inquiry
MiUTR3H-05928 SPAG1 miRNA 3'UTR clone Inquiry
CDCB182735 Rabbit SPAG1 ORF clone (XM_008255793.1) Inquiry
CDCR369630 Rat Spag1 ORF Clone(NM_001012116.1) Inquiry
Quick Inquiry