Pages
Products

SMAD2


Official Full Name
SMAD family member 2
Organism
Homo sapiens
Gene ID
4087
Background
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Synonyms
JV18; LDS6; CHTD8; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2

Cat.No. Product Name Price
AD15121Z Human SMAD2 adenoviral particles Inquiry
Cat.No. Product Name Price
SHH412960 shRNA set against Human SMAD2 (NM_005901.5) Inquiry
SHH412964 shRNA set against Mouse SMAD2 (NM_010754.5) Inquiry
SHH412968 shRNA set against Rat SMAD2 (NM_019191.1) Inquiry
SHL014974 shRNA set against Rat Smad2(NM_019191.1) Inquiry
SHW005073 shRNA set against Chicken SMAD2 (NM_204561) Inquiry
SHW014306 shRNA set against Danio rerio SMAD2 (NM_001290015) Inquiry
SHW014831 shRNA set against Danio rerio SMAD2 (NM_131366) Inquiry
Cat.No. Product Name Price
CDFR011489 Rat Smad2 cDNA Clone(NM_019191.1) Inquiry
MiUTR1R-07551 SMAD2 miRNA 3'UTR clone Inquiry
CDCB157153 Mouse SMAD2 ORF clone (NM_010754.4) Inquiry
CDCB166548 Chicken SMAD2 ORF Clone (NM_204561) Inquiry
CDCB175781 Danio rerio SMAD2 ORF Clone (NM_001290015) Inquiry
CDCB176306 Danio rerio SMAD2 ORF Clone (NM_131366) Inquiry
CDCB180894 Rabbit SMAD2 ORF clone (XM_008261278.1) Inquiry
CDCR378522 Rat Smad2 ORF Clone(NM_019191.1) Inquiry
Quick Inquiry