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SH2B3


Official Full Name
SH2B adaptor protein 3
Organism
Homo sapiens
Gene ID
10019
Background
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Synonyms
LNK; IDDM20

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SHH406482 shRNA set against Human Sh2b3 (NM_005475.2) Inquiry
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