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SELK


Official Full Name
selenoprotein K
Organism
Homo sapiens
Gene ID
58515
Background
The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Pseudogenes of this locus have been identified on chromosomes 6 and 19.[provided by RefSeq, Aug 2017]
Synonyms
SELENOK; SELK; HSPC030; HSPC297

Cat.No. Product Name Price
SHH404084 shRNA set against Human SELK (NM_021237.3) Inquiry
SHH404088 shRNA set against Mouse SELK (NM_019979.2) Inquiry
SHH404092 shRNA set against Rat SELK (NM_207589.3) Inquiry
SHR212888 shRNA set against Mouse Selk(NM_019979.2) Inquiry
SHR212988 shRNA set against Human SELK(NM_021237.3) Inquiry
SHW001153 shRNA set against Chicken SELK (NM_001025441) Inquiry
SHW007275 shRNA set against Danio rerio SELK (NM_001004681) Inquiry
Cat.No. Product Name Price
CDCR382414 Rat Selk ORF Clone(NM_207589.3) Inquiry
CDFG003304 Human SELK cDNA Clone(NM_021237.3) Inquiry
CDFR015338 Rat Selk cDNA Clone(NM_207589.3) Inquiry
MiUTR1H-09241 SELK miRNA 3'UTR clone Inquiry
MiUTR1M-10526 SELK miRNA 3'UTR clone Inquiry
MiUTR1R-03079 SELK miRNA 3'UTR clone Inquiry
CDCB162628 Chicken SELK ORF Clone (NM_001025441) Inquiry
CDCB168750 Danio rerio SELK ORF Clone (NM_001004681) Inquiry
CDCB186929 Rabbit SELK ORF clone (NM_001199833.1) Inquiry
CDCH078142 human SELK ORF clone (NM_021237.3) Inquiry
CDCH078146 Mouse Selk ORF clone (NM_019979.2) Inquiry
CDCS419485 Human SELK ORF Clone (BC013162) Inquiry
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