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Sel1h


Official Full Name
sel-1 suppressor of lin-12-like (C. elegans)
Organism
Mus musculus
Gene ID
20338
Background
Involved in ERAD pathway; protein secretion; and triglyceride metabolic process. Acts upstream of or within response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum. Predicted to be part of Derlin-1 retrotranslocation complex and Hrd1p ubiquitin ligase ERAD-L complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; liver; neural tube; pancreas; and spleen. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
Sel1l; Sel1h; mKIAA4137

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