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SCUBE3


Official Full Name
signal peptide, CUB domain and EGF like domain containing 3
Organism
Homo sapiens
Gene ID
222663
Background
This gene encodes a member of the signal peptide, complement subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1 and epidermal growth factor-like domain containing protein family. Overexpression of this gene in human embryonic kidney cells results in secretion of a glycosylated form of the protein that forms oligomers and tethers to the cell surface. This gene is upregulated in lung cancer tumor tissue compared to healthy tissue and is associated with loss of the epithelial marker E-cadherin and with increased expression of vimentin, a mesenchymal marker. In addition, the protein encoded by this gene is a transforming growth factor beta receptor ligand, and when secreted by cancer cells, it can be cleaved in vitro to release the N-terminal epidermal growth factor-like repeat domain and the C-terminal complement subcomponents C1r/C1s domain. Both the full length protein and C-terminal fragment can bind to the transforming growth factor beta type II receptor to promote the epithelial-mesenchymal transition and tumor angiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Synonyms
CEGF3; SSFSC2

Cat.No. Product Name Price
SHH403160 shRNA set against Human SCUBE3 (NM_152753.2) Inquiry
SHH403164 shRNA set against Mouse SCUBE3 (NM_001004366.1) Inquiry
SHR210214 shRNA set against Mouse Scube3(NM_001004366.1) Inquiry
SHR210286 shRNA set against Human SCUBE3(NM_152753.2) Inquiry
SHW014120 shRNA set against Danio rerio SCUBE3 (NM_001260501) Inquiry
Cat.No. Product Name Price
CDFG009791 Human SCUBE3 cDNA Clone(NM_152753.2) Inquiry
CDFG016883 Mouse Scube3 cDNA Clone(NM_001004366.1) Inquiry
MiUTR1H-09199 SCUBE3 miRNA 3'UTR clone Inquiry
MiUTR1M-10473 SCUBE3 miRNA 3'UTR clone Inquiry
CDCB175595 Danio rerio SCUBE3 ORF Clone (NM_001260501) Inquiry
CDCB182259 Rabbit SCUBE3 ORF clone (XM_008262809.1) Inquiry
CDCH077672 Mouse Scube3 ORF clone (NM_001004366.1) Inquiry
CDCR320096 Human SCUBE3 ORF Clone(NM_152753.2) Inquiry
CDCS417254 Human SCUBE3 ORF Clone (BC052263) Inquiry
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