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SCRIB

Official Full Name
scribble planar cell polarity protein
Organism
Homo sapiens
GeneID
23513
Background
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Synonyms
CRIB1; SCRB1; SCRIB1; Vartul; oSCRIB;

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