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SAE1

Official Full Name
SUMO1 activating enzyme subunit 1
Organism
Homo sapiens
GeneID
10055
Background
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Synonyms
AOS1; SUA1; UBLE1A; HSPC140;

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